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.us reccr is ieauired by law (7 USC 2143). Failure to reoon according 10 me regulations NOV 2 5 2002 See artacned form for

interagency Reocrt Control No.

cor

additional information

UNITED STATES DEPARTMENT OF AGRICULTURE

ANIMAL AND PUNT HEALTH INSPECTION SERVICE

1. CERTIFICATE NUMBER: 52-R-0007

CUSTOMER NUMBER: 493

FORM APPROVED /

OMB NO. 0573-0026 /

.... Hr

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

Virginia Commonwealth University
Division Of Animal Resources

P.O. Box 980630

Richmond, VA 23298

Telephone: (804) -828-9837

1 3. REPORTING FACILITY ( List all locations wnere animals were housed or used in actual research, testing, or expenmentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) - See Atached Listing

| REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILl^y^ttoci^ddit!onaisheetelfnecassa^^^jsa^PHI^Fonn7Q23AT

Animals Covered

By The Animal
Welfare Regulations

B. Number of
animats being
bred.

conditioned, or
held for use in
teaching,
testing,
experiments,
research, or
surgery but not ye

C. Number of
animals upon
which teaching,
research,
experiments, or

tests were

conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

D. Number of animals
upon which
expen men ts. teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropnate anesthetic, a

E. Number of animals upon which teaching,
expen men ts, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropnate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, expenments.
surgery, or tests. ( An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attacned to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

4. Dogs

5. Cats

6. Guinea Pigs

253

335

7. Hamsters

8. Rabbits

646

670

9. Non-human Primate

1 ) Professionally acceptable standards governing the care, treatment and use of animals, including appropnate use of anastatic, analgesic, and tranquilizing drugs, prior to, during, and following
actual research, teaching, tasting, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Cara and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the
iACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other asp ect s of animal care and

Column E Explanation

This form is intended as an aid to completing the Column E explanation. It is not an official form and its use is
'voluntary. Names, addresses, protocols, veterinary care programs, and the like, are not required as part of an
: explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.

.1. Registration Number 52-R-007

2. Number 31

!_ _ . rhesus

•3. Species (common name) monkevs

t
t

4. Explain the procedure producing pain and/or distress.

Thirty-one- rhesus monkeys were used as part of our program to evaluate
drug dependence liability of new compounds. These rhesus monkeys are
physically dependent on morphine and periodically allowed to go into
spontaneous withdrawal or withdrawal is precipitated by opiod antagonists.
During this time they undergo moderate to severe stress. On completion
of the observatiod period, withdrawal signs and symptoms are relieved by
an injection of morphine. It is important to note that these experiments are
repetitive in nature. A new investigational chemical is being tested on
each occasion. Many of these chemicals are opiod in nature and prevent
the appearance of the withdrawal signs and symptoms.

_of animals used in this study,
of animals used in the study.

.5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to
determine that pain and/or distress relief would interfere with test results. (For Federally mandated testing,
see Item 6 below)

The distress produced by this procedure is the end-point being measured.

• As indicated above, many of the compounds tested relieve these symptoms
and the experiment is terminated immediately after the observation

I period by the administration of morphine which also relieves the withdrawal

I signs.

*
t

i *

|6. What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations
(CFR) title number and the specific section number (e.g., APHIS, 9 CFR 1 13.102):

| The results from our testing program are used by both the FDA and DEA in

making decisions concerning the Controlled Substances Act.

Agency CFR

Column E Explanation

This form is intended as an aid to completing the Column E explanation. It is not an official form and its use is
voluntary. Names, addresses, protocols, veterinary care programs, and the like, are not required as part of an
explanation. A Column 5 explanation must be written so as to be understood by lay persons as well as scientist:

1. Reaistration Number 52-R-007

2. Number : of animals used in this study.

• •

3. Species (common name) guinea pig 0 f animals used in the study.

4. Explain $e orocedure producing pain and/or distress.

This laboratory uses a well-defined guinea pig- model of gallbladder inflama-
tion (acute cholecystitis) to evaluate the mechanisms that initiate acute
inf lamation.

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to
determine that pain and/or distress relief would interfere with test results. (For Federally mandated testing,
see Item 6 below)

Since analgesics inhibit inf lamation as part of their action, they wpuld
interfere with the study results. Most animals get analgesics/ anti i rift amatory
drugs as part of the experimental protocol, but about 30 % do not.

16. What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations
(CFR) title number and the specific section number (e.g., APHIS, 9 CFR 1 13.102):,

Agency N/ A

CFR N/A

This report is required by law (7 USC 2143) Failure to report according to the regulations can
result in an order to cease and desist and to be subject to penalties as provided for m Sea ion 2150.

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL ANO PLANT HEALTH INSPECTION SERVICE

See reverse side for Interagency Report Control No

50. additional information 0180-DOA-AN

ANNUAL REPORT OF RESEARCH FACILITY

(TYPE OR PRINT)

FORM APPROVED
0MB NO. 0579-0036

2. HEADQUARTERS RESEARCH FACILITY (Name and Address, as registered with USDA,
include Zip Code)

BLUE RIDGE COMMUNITY COLLEGE

U.S. ROUTE 11

WEYERS CAVE. VA 24486

1. REGISTRATION NO.

CUSTOMER NO.

52-R-0001

496

3. REPORTING FACILITY (List all locations where animals were housed or used in actual research, testing, teaching, or experimentation, or held for these purposes. Attach additional
sheets if necessary )

FACILITY LOCATION Sfsrfes)

See Attached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY (Attach additional sheets tf necessary or use APHIS FORM 7023A )

Animals Covered
By The Animal
Welfare Regulations

B. Number of
animals being
bred,

conditioned, or
held for use in
teaching, testing,
experiments,
research, or
surgery but not
yet used for such
purposes.

C. Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

0. Number of animals upon
which expenments.
teaching, research,
surgery, or tests were
conducted involving
accompanying pain or
distress to the animals
and for which appropriate
anesthetic analgesic or
tranquiiizing drugs were
used.

E. Number of animals upon which teaching,
expenments, research, surgery or tests were
conducted involving accompanying pain or distress
to tne animals and for which the use of appropriate
anesthetic analgesic, or tranquiiizing drugs would
have adversely affected the procedures, resuits, or
interpretation of the teaching, research,
expenments, surgery, or tests. (An explanation of
the procedures producing pain or distress in these
animals and the reasons such drugs were not used
must be attached to this report)

TOTAL NO.
OF ANIMALS

{Cols. C ♦
D*E)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-Human Primates

10. Sheep

1 1 . Pigs

1 2. Other Farm Animals

13. Other Animals

ASSURANCE STATEMENTS

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anesthetic analgesic and tranquiiizing drugs, poor to. during,
and following actual research, teaching, testing, surgery, or experimentation were followed by this research facility

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act and it has required that exceptions to the standards and regulations be specified and explained by the
pnncipal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of ail the exceptions is attached to this annual report. In
addition to identifying the IACUC -approved exceptions, this summary includes a bnef explanation of the exceptions, as well as the spaces and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authonty to ensure the provision of adequate veterinary care and to oversee the adequacy of other
aspects of animal care and use

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
(Chief Executive Officer or Legally Responsible Institutional official)

• ~ ** * above is true, correct, and complete (7 U.S.C. Section 2143)

I NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Print) I DAT!

which is obsolete

Tit) DATE SIGNED

iCjtf/£2-

PART 1 - HEADQUARTERS

This report s required by law (7 USC 2143). Failure to report according to the regulations
can

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

DEC l

2002 See attached form for
additional information

Interagency Report

rt Control Nc

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

1. CERTIFICATE NUMBER: 52-R-0002

FORM APPROVED

OMB NO. 0579-0036

CUSTOMER NUMBER: 504

College Of William And Mary

P.O. Box 8795

Williamsburg, VA 23187

Telephone: (804) -221-3967

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or expenmentation, or held for these purposes. Attach additional sheets if necessary )

£ (0 H'Ht FACILITY LOCATIONS ( Sites ) - See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY f Attach additional sheets if necessarv or use APHIS Form 7023A 1

Animals Covered
By The Animal
Welfare Regulations

Number of
animals being
bred, '

conditioned, or
heid for use in
teaching,
testing,
experiments,
research, or
surgery but not y€

Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

Number of animals
upon which
experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
anesthetic, analgesic, or tranquiiizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, experiments,
surgery, or tests. ( An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

4. Dogs

5. Cats

8 . Guinea Pigs

7. Hamsters

8 . Rabbits

9. Non-human Primate

10. Sheep

11. Pigs

12. Other Farm Animals

1 ) Professionally acceptable standards governing the care, treatment, and usa of animals, including appropriate use of anestetic, analgesic, and tranquiiizing drugs, prior to, during, and following
actual research, teaching, testing, surgery, or experimentation were followed by this research facility,

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of ail such exceptions Is attached to this annual report In addition to identifying the
lACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
( Chief Executive Officer or Legally Responsible Institutional Official )

$IG MATnnf: ftfrFn no institi iTinwAi nPCir.iAi

I NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL ( Tvpe Of Print

DATE SIGNED

i-JvloZ.

APH

Inis repon .s required Py taw (7 USC 2143). Failure to report according to the regulations
can

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

See attached form for
; / 0 r ‘ additional mf omnation

f ' t 1 *

1. CERTIFICATE NUMBER: 52-R-0003
CUSTOMER NUMBER: 497

Eastern Virginia Medical School
358 Mowbray Arch
P.O. Box 1980
Norfolk, VA 23501

Telephone: (804) -446-6010

Interagency Report Control No.

FORM APPROVEO
OMB NO 0579*0036

3. REPORTING FACILITY ( List all locations where animals were housed or used m actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

facility locations ( sues } -Division of Comparative Medicine, Lewis Hall

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY l Attach additional sheets If necessarv or use APHIS Form 7023A )

Animals Covered
By The Animal
Welfare Regulations

Number of
animals being-
bred.

conditioned, or
held for use in
teaching,
testing,
expenments.
research, or
surgery but not ye

Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

Number of animals
upon which
expenments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropnate anesthetic, a

E. Number of animals upon which teaching,
expenments. research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropnate
anesthetic, analgesic, or tranquiti&ng drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, expenments.
surgery, or tests. ( An explanation of (he procedures
producing pain or distress in these animats and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

1) Professionally acceptable standards governing the cara, treatment, and use of animals, including appropnate usa of anastatic, analgesic, and tranquilizing drugs, poor to, during, and following
actual research, teaching, testing, surgery, or experimentation ware followed by this resaarcri facility.

2) Each pnnapai investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act. and it has required that exceptions to the standards and regulations be specified and explained by the pnnapai
investigator and approved by the Institutional Animal Cara and Usa Committee (IACUC). A summary of ail such exceptions Is attached to this annual report In addition to identifying the
(AC UC -approved exceptions, this summary includes a brief explanation of the exceptions, as well as the spades and number of animals affected.

4) The attending vetennanan for this research facility has appropriate authority to ensure the provision of adequate veterinary cara and to oversee the adequacy of other aspects of animal care and

ERT1FICATION BY HEAOQUARTERS RESEARCH FACILITY OFFICIAL
( Chief Executive Officer or Legally Responsible institutional Official )

| NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL ( Type or Pnnt

| DATE SIGNED

iok*k&

APHIS FORM 7023
( AUG 91 )

(Replaces VS FORM 18-23 (OCT 88). which is obsolete.

This report is required by law (7 USC 2143). Failure to report according to the regulations
can "

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

Tv-

* t. L

7 Of- ,

See attached farm fpr
additional information

Interagency Report Control No.

1. CERTIFICATE NUMBER:

52-R-0004

CUSTOMER NUMBER:

498

ANNUAL REPORT OF RESEARCH FACILITY

(TYPE OR PRINT)

George Mason University
Asst Director Of Research Compliance
4400 University Drive, Ms 4c6
Fairfax, VA 22030

Telephone: (703) -993-. 2298

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

David King Hall Rms. 2036 and 2038 facility locations i Sita* ) - see Atached listing

Krasnow Building Room 122

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY f Attach additional sheets if necessarv or use APHIS Form 7023A )

Animals Covered
By The Animal
Welfare Regulations

Number of
animals being
bred.

conditioned, of
held for use in
teaching,
testing,
experiments,
research, or
surgery but not ye

Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

Number of animals
upon which
experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and fur which the use of appropriate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, expen ments,
surgery, or tests. ( An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

10. Sheep

11. Pigs

12. Other Farm Animals

1 ) Professionally acceptable standards governing me care, treatment, and use of animals, including appropriate use of anastatic, analgesic, and tranquilizing drugs, prior to, during, and following
actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Cara and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report In addition to identifying the
iACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
/ rw-f cvan .tiu e officer or Legally Responsible Institutional Official )

SIGN/

NAME & TITLE OF C.E.O OR INSTITUTIONAL OFFICIAL ( Type or Print

DATE SIGNED

^lnh>2

APHIS

( AUG 91 )

This - -sport is required by law (7 USC 2143). Failure to report according to the regulations can

See reverse side for

interagency Reoort Control No

result in an order to cease and desist and to be subject to penalties as provided for in Section 2150.

additional information.

0190-DOA-AN

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

52-R-0006

CUSTOMER NO.
507

FORM APPROVED
OMB NO. 0579-0036

ANNUAL REPORT OF RESEARCH FACILITY

(TYPE OR PRINT)

2. HEADQUARTERS RESEARCH FACILITY (Name and Address, as registered with USDA,
include Zip Code) » .

COVANCE LABORATORIES INC. NQ U Cj n
9200 LEESBURG TURNPIKE C Ofjp 0

VIENNA, VA 22182 %

l__ mojgxxxx (703) 245-2200

3. REPORTING FACILITY (List ail locations where animals were housed or used in actual research, testing, teaching, or experimentation, or held for these purposes. Attach additional

sheets if necessary.)

FACILITY LOCATlONSfsrfesj

See Attached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY f Attach additional sheets if necessary or use APHIS FORM 7023A )

Animats Covered
By The Animal
Welfare Regulations

9. Number of
animals being
bred.

conditioned, or
held for use in
teaching, testing,
experiments,
research, or
surgery but not
yet used for such
purposes.

C. Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

D. Number of animats upon
which experiments,
teaching, research,
surgery, or tests were
conducted Involving
accompanying pain or
distress to the animals
and for which appropriate
anesthetic, analgesic, or
tranquilizing drugs were
used.

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals ana for which the use of apptovriaie
an esthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research,
experiments, surgery, or tests. (An explanation of
the procedures producing pain or distress in these
animals and the reasons such drugs were not used
must be attached to this report)

TOTAL NO.

e % ut a * i ^

(Cols. C ♦
D ♦ E)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-Human Primates

10. Sheep

11. Pigs

12. Other Farm Animals

13. Other Animals

ASSURANCE STATEMENTS

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anesthetic, analgesic, and tranquilizing drugs, prior to. during,
and following actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhenng to the standards and regulations under the Act and it has required that exceptions to the standards and regulations be specified and explained by the
principal investigator and approved by the Institutional Animal Care and Use Committee (lACUC). A summary of all the exceptions is attached to this annual report In
addition to identifying the lACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
_ fChi#»f Executive Officer or Legally Responsible Institutional official)

bove is true, correct, and complete (7 U.S.C. Section 2143)

I NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Print) | DAI

DATE SIGNED

///.

APHIS FORM 7023

(AUG 91)

(Replaces VS FORM 18*23 (Oct 88), which is obsolete

PART 1 - HEADQUARTERS

This report is required by law (7 USC 2143). Failure to report according to the regulations
can

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

NOV £ 2 2002 See attached form for

additional information

1. CERTIFICATE NUMBER: 52-R-0009
CUSTOMER NUMBER: 494

Interagency Report Control No.

FORM APPROVED
OMB NO. 0579-0036

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

Old Dominion University
2.1Q-New Ad m i nistra tioo-BIdg
BStfclESZBilZJSZa.

Telephone: 4804)-§83-3707

(757) 683-3460

Office of Research
2035 Hughes Hall
Norfolk, VA 23529

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additipnal sheets if necessary )

FACILITY LOCATIONS ( Sites ) - See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY l Attach additional sheets if necessarv or use APHIS Form 7023A \

Animals Covered
By The Animal
Welfare Regulations

Number of
animals being
bred.

conditioned, or-
held for use in
teaching,
testing,
experiments,
research, or
surgery but not y€

Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

Number of animals
upon which

experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropnate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, expenments.
surgery, or tests. ( An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

10. Sheep

1 1 . Pigs

12. Other Farm Animats

13. Other Animals

ASSURANCE STATEMENTS

1 ) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anastatic, analgesic, and tranquilizing drugs, prior to. during, and following
actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report. In addition to identifying the
IACUC -approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropnate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
( Chief Executive Officer or Legally Responsible Institutional Official )

I uauc sl Tin c oc r c r\ no iKJcrm mnwAi nceirMAi / r„r>* nr Dnnt

DATE SIGNED

lil/15/o:

APHIS FORM 7023
(AUG 91 ).

(Replaces VS FORM 18-23 (OCT 88). which is obsolete.

Sep 27 02 10:24a

(b)(6), (b)(7)c

SEP-24-02 08:58AM FROH-VP for RESEARCH 1 PUBLIC SERVICE -

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can

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

OCT 0 7 7002

ANNUAL REPORT OF RESEARCH FACILITY

( TVPE OR PRINT )

p. 1

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P 004/008 F-487

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V CERTIFICATE NUMBER; 52-R-0D11

CUSTOMER NUMBER: 495

FORM APPQQVfcD
CM0 NO. 0573-0039

University Of Virginia

Was hi n g to n Hati E R an ge 3N MLL.

Office OI The Vice President For Peeoarch
Chariottosvilio, VA-229W- c£Pfoti

^3h

Telophone: -{$04) -924*3606

fAX

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Facility locations ( sum j - stt Amcaca u»ung

(\\

REPORT Of ANIMALS USED BY OR UNDER CONTROL Of RESEARCH FACILITY i Ansel . Additional itedi If n^iiuiv g* M » APHIS Form 7023 a \

; 8. MaMoi
j antmsis bclitf

AiOfUMl Cm*rM
By 78 m AaMmI

Welto fUgahllong

x Dog*

1 Cat*

o, Guinea

7. Kam liars

0. Norvhumon Ffimsie

10. Stop

11 PJQ3

12. Other farm Animals

Risk shrews

13, OttoAnimatt

conOMcrtd, or
l**J« Imt um *

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iMitnx

eapcrWwnic,

'•*•>401. or

•WfoykUMiy*

126

264

C. ttosarof
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*wcn icacntpg,
riMww.

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conducted

IfNOMAOnO

pab, dfjkes*. u»

uaanf rial*.

r®tt**ln#dfvQ9.

O* Nuirhrr <rf xMm* k
upon urn m
•kpaflMMdh. teai 'lag.
retaven. suw*. or

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^crying

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dtoa totm an n«M
sndfgr widen
AOOrorLda anal »clc, 3

C* NLxr«>«r at an*r*ij uccn ireerwkg.
etgcnmedx research. swrgory or teals
conductor ift%OMnQ KCQfrpanjiftg coin or Chucu
la ins a/umais *M Car unlen lha tea ol •epropnst*
arwuhede >A9iqai4c. or trsngumUftp drugs would
nave advirsaly aMMlad ttw precodu*^ reiuns. gr
•'"erp'cohon d uis ‘*acn«a. ruaircn. upervoeMs,

iurge/y. or teats. ( An e^obnaVon «yf ipc procedure*
producing pMn or AsS*t»g « rm$ lOal AM me
rexwng mch drugs aoi not used crust M aiutod <0

TOTAL NUM95A
OF ANIMALS

( COLUMNS
C + 0+ £)

132

:.ioo

100 i

i 1

i 0 1

i 200

AsaimAwcf. statements

1| frc tmtoay taaapia

oaual nwaareft. l aK h P ft , Isfdng. angry,

r««ng r» cant toto* end to * toto. litCWlR ap voprtata to * fttutite, AMto* and VanqvBZlftg Oust Qftor W. and Mtoog

or eoartoseuen wait Risasssy iaa m i t or ch facaiy

R iM*taeOnyitsonarineiana«iar»sms

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ai# rasumarnt leiasr me wnu a »«

orf >S sucti eaeaotlBM Is Httenad la this v*w*

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CSRTlf tCATlON BY HEAOQUARTtR » Kt^AHCM f ACiUTT OPMCVM.
( Chief Ex&arfve Omeef of Legally Ri sponoihie bi&tuikytai Cflkial )

I NAUE A TfT C Qjr MT ft on imCTTTI mnMAi QPFlCtAL f 7\*imafPtW

(CATE SIGNED

Afros pgiw 7023
t*U0 91 )

(RWltes VS FORM TB»23 (OtT 99), often 'J OOtQWia.

This report ts required by law (7 USC 2143). Failure (o report according to the regulations
can

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

NOV 2 1 2002

See attached form for
additional information

Interagency Report Control No.:

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

1. CERTIFICATE NUMBER:

52-R-0012

CUSTOMER NUMBER:

492

V A Polytechnic Institute & State University
110 Litton-Reaves Hall
Blacksburg, VA 24061

Telephone: (540) -231-4991

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) - See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY i Attach additional sheets if necessarv or use APHIS Form 7023A \

Animals Covered
By The Animal
Welfare Regulations

Number of
animals being
bred,

conditioned, or
held for use in
teaching,
testing,
experiments,
research, or
surgery but not ye

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

10. Sheep

11. Pigs

Horses

1 3. Other Animals Ca 1 1 e

Bears

Punare

Peromyscus

ASSURANCE STATEMENTS

1 2. Other Farm Animals Goats

Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

100

Number of animals
upon which
experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

338

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, experiments,
surgery, or tests. ( An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER

OF ANIMALS

( COLUMNS
C+D+E)

351

100

1 ) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following
actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report. In addition to identifying the
LACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
( Chief Executive Officer or Legally Responsible Institutional Official )

a tti inr

n uliotiti itiamai s \ r ;

FICIAL

NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL ( Type or Print

DATE SIGNED

t ///§/'.;+

APHIS fORM 7023
( AUG 91 )

(Replaces VS FORM 18-23 (OCT 88), which is obsolete.

result m an order lo cease and desist and to be subject to penalties as provided tor in Section 2150

additional information

01 80-OOA-AN

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

FORM APPROVED
0M8 NO 0579-0036

i. registration no. 52 — R- 00 12
Cust. #: 492

2. HEADQUARTERS RESEARCH FACILITY (Name and Address . as registered with USDA.
include Zip Code )

VA Polytechnic Institute 6c State University
110 Lit ton-Reaves Hall

Blacksburg, VA 24061-0329 NOV 2 1 2002
Telephone: (540) 231-4991

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY ( Attach adiilitional sheets il necessary or use this lorn )

CONTINUATION SHEET FOR ANNUAL REPORT

OF RESEARCH FACILITY

( TYPE OR PRINT)

Animals Covered
By The Animal
Welfare Regulations

12. &/OR 13 Other
(List by species)

Microtus (voles)

B. Number of
animals being
bred.

conditioned, or
hetdJor use m
teaching, testing,
experiments,
research, or
surgery but not
yet used tor such
purposes.

C Number ol
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

0- Number of animals upon
which experiments,
teaching, research,
surgery, or tests were
conducted involving
accompanying pain or
distress to the animals
and tor which appropriate
anesthetic, analgesic, or
iranqutiizmg drugs were
used.

E Number ot animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research,
experiments, surgery, or tests. (An explanation of
the procedures producing pain or distress in these
animals and the reasons such drugs were not used
must be attached to this report).

total no.

OF ANlMALs

(Cois. C ♦

D + E)

1) . Professionally acceptable standards governing the caie, treatment, and use of animals, including approbate use of anesthetic, analgesic, and Iranquitizing drugs, prior ro, during,

and following actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) . Each principal investigator has considered alternatives lo pamtul procedures.

3) . This facility is adhering to the standards and regulations under the Act. and it has required that exceptions to the standards and regulations be specified and explained by the

principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of alt such exceptions is attached to this annual report, in
addition to identifying (he lACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as welt as the species and number ol animals affected

4) . The attending veterinarian for this research facility hus appropriate authority to ensure the provision of adequate veterinary care and to oversee the auequacy of other aspects of

animal care and use.

CERTIFICATION BY IIEADQUAKTES RESEARCH FACILITY OFFICIAL
(Chief Executive Officer or Legally Responsible Institutional Official)

I certify that the above is true, correct, and complete (7 U S C Section 21 43)

DNAL OFFICIAL I NAME & TITLE OF C.EO. OR INSTITUTIONAL OFFICIAL (Type or Print) I 0ATE SIGNE

AKhlb rUMM /UxfJM

(AUG 91 )

PART 1 - HEADQUARTERS

WW OUOUICU I III IUI

irueiayenuy nepon uontroi ISO.:

tms repon is requireo oy law {t uop zi*o). ranure 10 report accoratny io me (eyuiauuns
can

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

NOV 9?

additional information

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

1. CERTIFICATE NUMBER: 52-R-0013
CUSTOMER NUMBER: 482

Washington And Lee University
Parmly Hall
Lexington, VA 24450

457

Telephone: (540) -460-8895

FORM APPROVED
OMB NO. 0579-0036

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) - See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY ( Attach additional sheets if necessarv or use APHIS Form 7023A \

Animals Covered
By The Animal
Welfare Regulations

Number of
animals being
bred,

conditioned, or"
held for use in
teaching,
testing,
experiments,
research, or
surgery but not ye

Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

Number of animals
upon which
experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
anesthetic, analgesic, or tranquitizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, experiments,
surgery, or tests. ( An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Norr-human Primate

10. Sheep

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following
actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Care and Use Committee (1ACUC). A summary of all such exceptions is attached to this annual report In addition to identifying the
IACUC -approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research fadlity has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
( Chief Executive Officer or Legally Responsible Institutional Official )

SIGN)*

APHIS I

Ti ioc np rt r- e\ p\n unfrin itiaili«i ftrriPMi

NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL ( Type or Print

DATE SIGNED

IhZS'Oi

This report is required by law (7 USC 2143). Failure to report according to the regulations
can

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

OE c 1 6 2002 s ee attached form for

additional information

1. CERTIFICATE NUMBER:

52-R-0014

CUSTOMER NUMBER:

753

Interagency Report Control

FORM APPROVED
OMB NO. 0579-0036

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

Duncroft, Inc.

39166 Irish Comer Rd.
Lovettsville, VA 20180

Telephone: (540) -822-5883

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) - See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY l Attach additional sheets if necessarv or use APHIS Form 7023A \

Animals Covered
By The Animal
Welfare Regulations

Number of
animals being
bred,

conditioned, or
held for use in
teaching,
testing,
experiments,
research, or
surgery but not y€

Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

Number of animals
upon which
experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, experiments,
surgery, or tests. ( An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

10. Sheep

11. Pigs

12. Other Farm Animals

13. Other Animals

I6H

(oO

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following
actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report In addition to identifying the
lACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4} The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
( Chief Executive Officer or Legally Responsible Institutional Official )

(»i/'n*Ttinr nr r- /-\r» i h i C'ttti it a i Arrt/^ i a i

NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL ( Type or Print

°HiS FORM 7023
' )

(Replaces VSVORM 18-23 (OCT 88), which is obsolete.

This report ts required by law (7 USC 2143). Failure to report according to the regulations NflV 1 4 See attached form for

cgn 4 u T J. ^ additional information

Interagency Report Control No.:

UNITED STATES DEPARTMENT OF AGRICULTURE

ANIMAL AND PLANT HEALTH INSPECTION SERVICE

1. CERTIFICATE NUMBER: 52-R-0029

CUSTOMER NUMBER: 483

FORM APPROVED \fN^
OMB NO. 0579-0036^-

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

Northern Virginia Community College
Veterinary Technology Program

1000 Harry Flood Byrd Highway

Sterling, VA 20164

Telephone: (703) -450-2525

3. REPORTING FACILITY ( List ail locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) - See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY ( Attach additional sheets if necessary or use APHIS Form 7023A \

Animals Covered

By The Animal
Welfare Regulations

B. Number of
animals being
bred,

conditioned, or
held for use in
teaching,
testing,
experiments,
research, or
surgery but not ye

C. Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

D. Number of animals
upon which
experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

E. Number of animals upon which teaching,
expenments. research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, experiments,
surgery, or tests. { An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

4. Dogs

~73

jer

5. Cats

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

10. Sheep

11. Pigs

12. Other Farm Animals

13. Other Animals

ASSURANCE STATEMENTS

1} Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following
actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Care and Use Committee (LACUC). A summary of all such exceptions Is attached to this annual report In addition to identifying the
1ACUC -approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
( Chief Executive Officer or Legally Responsible Institutional Official )

SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL

I NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL ( Tvoe or Print

I DATE SIGNED

'opyA

s obsolete.

( AUG 91 )

This report is required by law (7 USC 2143). Failure to report according to the regulations
can

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

NOV 1 4 2002

See attached fcim for
additional information

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

1. CERTIFICATE NUMBER: 52-R-0029
CUSTOMER NUMBER: 483

Northern Virginia Community College
Veterinary Technology Program
1000 Harry Flood Byrd Highway
Sterling, VA 20164

Telephone: (703) -450-2525

Interagency Report Control No.

FORM APPROVED
OMB NO. 0579-0036

3. REPORTING FACILITY { List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) * See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY ( Attach additional sheets If necessarv or use APHIS Form 7023A )

Animals Covered
By The Animal
Welfare Regulations

Number of
animals beingr
bred.

conditioned, or
held for use in
teaching,
testing,
experiments,
research, or
surgery but not ye

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

10. Sheep

11. Pigs

1 2. Other Farm Animals

13. Other Animals

C. Number of

D. Number of animals

animals upon

upon which

which teaching.

experiments, teaching.

research.

research, surgery, or

experiments, or

tests were conducted

tests were

involving

conducted

accompanying pain or

involving no

distress to the animais

pain, distress, or

and for which

use of pain-

appropriate anesthetic, a

relieving drugs.

"73

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, experiments,
surgery, or tests. ( An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

ASSURANCE STATEMENTS

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anastatic, analgesic, and tranquilizing drugs, prior to, during, and following
actual research, teaching, tasting, surgery, or experimentation were followed by this research facility.

2} Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Cara and Use Committee (IACUC). A summary of all such exceptions Is attached to this annua! report. In addition to identifying the
lACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

Interagency Report Control No.:

This report is required by law (7 USC 2143). Failure to report according to the regulations
can

NOV 1 4 2002

See attached form for
additional information

UNITED STATES DEPARTMENT OF AGRICULTURE

1. CERTIFICATE NUMBER: 5?.R-0f)?9

FORM APPROVED !

ANIMAL AND PLANT HEALTH INSPECTION SERVICE

CUSTOMER NUMBER: 483

OMB NO. 0579-0036 J

Northern Virginia Community College

ANNUAL REPORT OF RESEARCH FACILITY

Veterinary Technology Program

( TYPE OR PRINT )

1000 Harry Flood Byrd Highway

Sterling, VA 20164

Telephone: (703) -450-2525

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) - See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY / Attach additional sheets if neeessarv or use APHIS Form 7023A \

Animals Covered

By The Animat
Welfare Regulations

B, Number of
animals being-
bred.

conditioned, or
held for use in
teaching,
testing,
experiments,
research, or
surgery but not ye

C. Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

D. Number of animals
upon which
experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropnate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, experiments,
surgery, or tests. ( An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

4. Dogs

5. Cats

x ...

6. Guinea Pigs

•

7. Hamsters

•

8. Rabbits

9. Non-human Primate

10. Sheep

11. Pigs

1 2. Other Farm Animals

13. Other Animals

— . , r

i »

ASSURANCE STATEMENTS

1 ) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquflizing drugs, prior to. during, and following
actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Care and Use Committee (1ACUC). A summary of all such exceptions Is attached to this annual report* In addition to identifying the
lACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as welt as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

{ AUG 91 )

This report is required by law (7 USC 2U3). Failure lo report according lo the regulations
can

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

NOV 1 4 2002

See attached form for
additional information

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

1. CERTIFICATE NUMBER: 52-R-0029
CUSTOMER NUMBER: 483

Northern Virginia Community College
Veterinary Technology Program
1000 Harry Flood Byrd Highway
Sterling, VA 20164

Telephone: (703) -450-2525

Interagency Report Cc

FORM APPRl
OMB NO. 0575^,

3 . REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) - See Atached Usting

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY l Attach additional sheets If necessarv or use APHIS Form 7023A \

Animals Covered
By The Animal
Welfare Regulations

Number of
animals being--
bred,

conditioned, or
held for use in
teaching,
testing,
experiments,
research, or
surgery but not ye

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

10. Sheep

11. Pigs

12. Other Farm Animals

C. Number of

D. Number of animals

animals upon

upon which

which teaching.

experiments, teaching.

research.

research, surgery, or

experiments, or

tests were conducted

tests were

involving

conduded

accompanying pain or

involving no

distress, to the animals

pain, distress, or

and for which

use of pain-

appropriate anesthetic, a

relieving drugs.

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, experiments,
surgery, or tests. { An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following
actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3} This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal

investigator and approved by the Institutional Animal Care and Use Committee (tACUC). A summary of all such exceptions Is attached to this annual report. In addition to identifying the
lACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the s pedes and number of animals affected.

4) The attending veterinarian for this research fadlity has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
( Chief Executive Officer or Legally Responsible Institutional Official )

SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL

I NAMP Jt TITI rnerm no IN.QTTT! rrmWAI nPPtriAl / Tvnm nr Print

I DATE SIGNED

tyjyA

APHIS rwruvi /u
( AUG 91 )

vo rurvivi iu*^j ^wi uu/, wuiw

. .s obsolete.

See attached form for Interagency Report Control No.:

additional information

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

3. REPORTING FACILITY ( List ail locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) - See Atached Listing

1. CERTIFICATE NUMBER: 52-R-0103
CUSTOMER NUMBER: 485

FORM APPROVED

OMB NO. 0579-Oqae

/ r

PPL Therapeutics, Inc.
1700 Kraft Drive
Suite 2400

Blacksburg, VA 24060
Telephone: (540) -961-5559

ipt

OCT 2 5 20u

n';

This report is required by law (7 USC 2143). Failure to report according to the regulations
can

| REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY 1 Attach additional sheets If necessary or use APHIS Form 7023A \ \

Animals Covered

By The Animal
Welfare Regulations

B. Number of
animals being-
bred,

conditioned, or
held for use in
teaching,
testing,
experiments,
research, or
surgery but not yc

C. Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-

D. Number of animals
upon which
experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, experiments,
surgery, or tests. ( An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

5. Cats

6. Guinea Pigs

7. Hamsters

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anastatic, analgesic, and tranquiKzing drugs, prior to, during, and following

actual research, teaching, tasting, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such sxceptions Is attached to this annual report in addition to identifying the
lACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
( Chief Executive Officer or Legally Responsible Institutional Official )

Arnu> ruKM /u^o tKepoces FORM 18*23 (OCT 88), which is obsolete.

( AUG 91 )

Facility locations: PPL Therapeutics Inc.

Farm location
3075 Catawba Road
Blacksburg, VA 24060

VPI Central Viviarium
Litton Reaves Hall
Blacksburg, VA 24061

This report is required by law (7 USC 2143). Failure to report according to the regulations
can __

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

See attached form for
additional information

Interagency Report Control No.:

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

1. CERTIFICATE NUMBER; 52-R-0105

CUSTOMER NUMBER: 1 662

FORM APPROVED y/

OMB NO. 0579-0036

University Of Richmond

28 Westhampton Way

Richmond, VA 23173 fl/Q j

Telephone: (999) -999-9999

f ^2 2002

3. REPORTING FACILITY { List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) * See Atached Usting

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY ( Attach additional sheets if necessary or use APHIS Form 7023A \

Animals Covered
By The Animal
Welfare Regulations

Number of
animals being
bred,

conditioned, or
held for use in
teaching,
testing,
experiments,
research, or
surgery but not ye

Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

Number of animals
upon which
experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

10. Sheep

11. Pigs

12. Other Farm Animals

1 ) Professionally acceptable standards governing the care, treatment and use of animals, including appropriate use of anestetic, analgesic, and tranquiiizing drugs, prior to, during, and following
actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report In addition to identifying the
LAC UC -approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
( Chief Executive Officer or Legally Responsible Institutional Official )

SfriM ati idc r\c n c r\ no imctiti iTirtMAt nrnriAl

NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL ( Type or Print

DATE SIGNED

IH8-<n

APMI£> l-UKM /UZJ
( AUG 91 )

replaces vo rursivn iuv^t ooj. wmch is obsolete.

November 1 8, 2002

Certificate Number 52-R-0105

Facility Locations
University of Richmond
University of Richmond, V A 23173

Telephone number - 804/289-8417

Gottwald Science Center Biology and Chemistry

Richmond Hall Psychology

This report is required by law (7 USC 2143). Failure to report according to the regulations can
result in an order to cease and desist and to be subject to penalties as provided for in Section 2150.

See reverse side for
additional information.

Interagency Report Control No
0180-DOA-AN

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PUNT HEALTH INSPECTION SERVICE

ANNUAL REPORT OF RESEARCH FACILITY

(TYPE OR PRINT)

1. REGISTRATION NO.

52-R-0106

CUSTOMER NO.
12652

FORM APPROVED
OMB NO. 0579-0036

2. HEADQUARTERS RESEARCH FACILITY (Name and Address, as registered with USDA,
in dude Zip Code)

VA SCIENTIFIC RESEARCH, INC.

1866 E MARKE ST, SUITE 327
HARRISONBURG, VA 22801

FACILITY LOCATIONS (sites)

VA SCIENTIFIC RESEARCH, INC.
BROADWAY, VA 22815

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY (Attach additional sheets if necessary or use APHIS FORM 7023A )

Animals Covered
By The Animal
Welfare Regulations

B. Number of
animals being
bred,

conditioned, or
held for use in
teaching, testing,
experiments,
research, or
surgery but not
yet used for such
purposes.

Number of
animals upon
which teaching,
research,
experiments, or
tests were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

Number of animals upon
which experiments,
teaching, research,
surgery, or tests were
conducted involving
accompanying pain or
distress to the animals
and for which appropriate
anesthetic, analgesic, or
tranquilizing drugs were
used.

E. Number erf animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
ane$thetic,analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research,
experiments, surgery, or tests. (An explanation of
the procedures produdng pain or distress in these
animals and the reasons such drugs were not used
must be attached to this report)

TOTAL NO.
OF ANIMALS

(Cols. C +

D + E)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-Human Primates

10. Sheep

1 1 . Pigs

12. Other Farm Animals

13. Other Animals

ASSURANCE STATEMENTS

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the
principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all the exceptions Is attached to this annual report. In
addition to identifying the lACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL
(Chief Executive Officer or Legally Responsible Institutional official)

l certify that the above is true, correct, and complete (7 U.S.C. Section 2143)

| SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL

NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Print)

DATE SIGNED

01/08/2003

APHIS FORM 7023
(AUG 91)

(Replaces VS FORM 18-23 (Oct 88), which is obsolete

PART 1 - HEADQUARTERS

This report is required by law (7 USC 2143). Failure to report according to the regulations
can

UNITED STATES DEPARTMENT OF AGRICULTURE
ANIMAL AND PLANT HEALTH INSPECTION SERVICE

See attached form for
additional information

Interagency Report Control No.

ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

1. CERTIFICATE NUMBER: 52-R-0107

CUSTOMER NUMBER: 12155

FORM APPROVED

OMB NO. 0579-0036

Operational And Emergency Medical Support Group

Skills Course

10201 Fairview

Partlow, VA 22534 ^

WV 2 9 2002

Telephone: (301) -610-2180

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FACILITY LOCATIONS ( Sites ) - See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY / Attach additional sheets if necessarv or use APHIS Form 7023A \

Animals Covered
By The Animal
Welfare Regulations

Number of
animals being
bred.

conditioned, or
held for use in
teaching,
testing,
experiments,
research, or
surgery but not ye

Number of
animals upon
which teaching,
research,
experiments, or
‘.er*s were
conducted
involving no
pain, distress, or
use of pain-
relieving drugs.

Number of animals
upon which
experiments, teaching,
research, surgery, or
tests were conducted
involving

accompanying pain or
distress to the animals
and for which
appropriate anesthetic, a

E. Number of animals upon which teaching,
experiments, research, surgery or tests were
conducted involving accompanying pain or distress
to the animals and for which the use of appropriate
anesthetic, analgesic, or tranquilizing drugs would
have adversely affected the procedures, results, or
interpretation of the teaching, research, experiments,
surgery, or tests. { An explanation of the procedures
producing pain or distress in these animals and the
reasons such drugs were not used must be attached to

TOTAL NUMBER
OF ANIMALS

( COLUMNS
C+D+E)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

10. Sheep

11. Pigs

12. Other Farm Animals

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal
investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the
lACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as welt as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

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